![]() ![]() This allows for protein identification and 3D mapping of molecular complexes at the single-molecule level. DNA Nanoswitch Calipers (DNCs) offer a transformative approach to proteomics, marrying DNA nanotechnology with single-molecule manipulation to measure atomic-level distances. Proteins, essential orchestrators of life and disease, must be understood in detail to enable their use in basic research and practical applications in diagnostics and therapeutics. ![]() Credit: Wyss Institute at Harvard University DNA Nanoswitches: Single-molecule proteomics DNA Nanoswitch Calipers (DNCs) combine DNA nanotechnology with single-molecule manipulation to measure atomic-level distances, allowing for protein identification and 3D mapping of molecular complexes at the single-molecule level. They also collaborate with key opinion leaders, investors, and potential customers to de-risk their innovations and speed their progress to the market. Over the course of the year, project teams pursue initial use-cases for their technologies that have the potential for significant positive impact. 13 projects selected to receive Validation Project support to advance commercialization and impactĮach year we name a class of Validation Projects whose teams receive dedicated funding, business development support, and additional resources to advance their technologies towards commercialization.
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